Epithelial-Myoepithelial Carcinoma of the Breast with Rhabdoid Features
Epithelial-myoepithelial carcinoma of the breast is a rare biphasic tumor composed of intermixed malignant epithelial and myoepithelial components. Myoepithelial cells are known to adopt varied morphologies, including spindle, chondroid, clear cell, and rhabdoid morphologies, and can represent a dia...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2020/8879035 |
| _version_ | 1826821105932828672 |
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| author | Karl Grenier Gulbeyaz Altinel Zari Dastani Atilla Omeroglu |
| author_facet | Karl Grenier Gulbeyaz Altinel Zari Dastani Atilla Omeroglu |
| author_sort | Karl Grenier |
| collection | DOAJ |
| description | Epithelial-myoepithelial carcinoma of the breast is a rare biphasic tumor composed of intermixed malignant epithelial and myoepithelial components. Myoepithelial cells are known to adopt varied morphologies, including spindle, chondroid, clear cell, and rhabdoid morphologies, and can represent a diagnostic challenge when isolated on biopsy. Rhabdomyosarcoma, phyllodes tumor, metaplastic carcinoma, and myoepithelial carcinoma are primary breast tumors that all have been shown to exhibit rhabdoid features, whether representing true differentiation or morphological mimic. We here report an epithelial-myoepithelial carcinoma of the breast with rhabdoid features in a 76-year-old woman. The rhabdoid-appearing myoepithelial cells are negative for myogenin, consistent with a rhabdoid-like morphology rather than a true rhabdoid differentiation, comparably to previously described myoepithelial carcinoma with rhabdoid features. To our knowledge, this is the first reported case of epithelial-myoepithelial carcinoma of the breast with rhabdoid features and thus adds another entity to the differential diagnosis of breast lesions with rhabdoid features. |
| first_indexed | 2025-02-16T06:40:15Z |
| format | Article |
| id | doaj.art-08949ef715c1495f86ab0d7d280c702f |
| institution | Directory Open Access Journal |
| issn | 2090-6781 2090-679X |
| language | English |
| last_indexed | 2025-02-16T06:40:15Z |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj.art-08949ef715c1495f86ab0d7d280c702f2025-02-03T06:43:31ZengWileyCase Reports in Pathology2090-67812090-679X2020-01-01202010.1155/2020/88790358879035Epithelial-Myoepithelial Carcinoma of the Breast with Rhabdoid FeaturesKarl Grenier0Gulbeyaz Altinel1Zari Dastani2Atilla Omeroglu3Department of Pathology, McGill University Health Center, 1001 Decarie Blvd, Montreal, Québec, H4A 3J1, CanadaDepartment of Pathology, McGill University Health Center, 1001 Decarie Blvd, Montreal, Québec, H4A 3J1, CanadaDépartement de Pathologie, Centre Hospitalier de Lanaudière, 1000 Boulevard Sainte-Anne, Saint-Charles-Borromée, Québec, J6E 6J2, CanadaDepartment of Pathology, McGill University Health Center, 1001 Decarie Blvd, Montreal, Québec, H4A 3J1, CanadaEpithelial-myoepithelial carcinoma of the breast is a rare biphasic tumor composed of intermixed malignant epithelial and myoepithelial components. Myoepithelial cells are known to adopt varied morphologies, including spindle, chondroid, clear cell, and rhabdoid morphologies, and can represent a diagnostic challenge when isolated on biopsy. Rhabdomyosarcoma, phyllodes tumor, metaplastic carcinoma, and myoepithelial carcinoma are primary breast tumors that all have been shown to exhibit rhabdoid features, whether representing true differentiation or morphological mimic. We here report an epithelial-myoepithelial carcinoma of the breast with rhabdoid features in a 76-year-old woman. The rhabdoid-appearing myoepithelial cells are negative for myogenin, consistent with a rhabdoid-like morphology rather than a true rhabdoid differentiation, comparably to previously described myoepithelial carcinoma with rhabdoid features. To our knowledge, this is the first reported case of epithelial-myoepithelial carcinoma of the breast with rhabdoid features and thus adds another entity to the differential diagnosis of breast lesions with rhabdoid features.http://dx.doi.org/10.1155/2020/8879035 |
| spellingShingle | Karl Grenier Gulbeyaz Altinel Zari Dastani Atilla Omeroglu Epithelial-Myoepithelial Carcinoma of the Breast with Rhabdoid Features Case Reports in Pathology |
| title | Epithelial-Myoepithelial Carcinoma of the Breast with Rhabdoid Features |
| title_full | Epithelial-Myoepithelial Carcinoma of the Breast with Rhabdoid Features |
| title_fullStr | Epithelial-Myoepithelial Carcinoma of the Breast with Rhabdoid Features |
| title_full_unstemmed | Epithelial-Myoepithelial Carcinoma of the Breast with Rhabdoid Features |
| title_short | Epithelial-Myoepithelial Carcinoma of the Breast with Rhabdoid Features |
| title_sort | epithelial myoepithelial carcinoma of the breast with rhabdoid features |
| url | http://dx.doi.org/10.1155/2020/8879035 |
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