A specific tongue microbiota signature is found in patients displaying an improvement of orosensory lipid perception after a sleeve gastrectomy
IntroductionA preferential consumption of low-fat foods is reported by most of the patients after a vertical sleeve gastrectomy (VSG). The fact that a recent study shed light on a relationship between oral microbiota and fat taste sensitivity in obese patients prompted us to explore whether such a c...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.1046454/full |
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| author | Arnaud Bernard Loredana Radoi Jeffrey Christensen Florence Servant Vincent Blasco-Blaque Séverine Ledoux Xavier Collet Philippe Besnard |
| author_facet | Arnaud Bernard Loredana Radoi Jeffrey Christensen Florence Servant Vincent Blasco-Blaque Séverine Ledoux Xavier Collet Philippe Besnard |
| author_sort | Arnaud Bernard |
| collection | DOAJ |
| description | IntroductionA preferential consumption of low-fat foods is reported by most of the patients after a vertical sleeve gastrectomy (VSG). The fact that a recent study shed light on a relationship between oral microbiota and fat taste sensitivity in obese patients prompted us to explore whether such a connection also exists in the context of a VSG.MethodsThirty-two adult female patients with a severe obesity (BMI = 43.1 ± 0.7 kg/m2) and candidates for a VSG were selected. Oral microbiota composition surrounding the gustatory circumvallate papillae (CVP) and the lipid perception thresholds were explored before and 6 months after surgery.ResultsVSG was found to be associated both with a qualitative (compositional changes) and quantitative (lower gene richness) remodeling of the peri-CVP microbiota. Analysis of the lipid perception allowed us to distinguish two subgroups: patients with a post-operative improvement of the fat taste sensitivity (i.e., with a lower threshold, n = 14) and unimproved patients (n = 18). Specific peri-CVP microbiota signatures also discriminated these two subgroups, unimproved patient being characterized by higher levels of Porphyromonas, Fusobacterium, and Haemophilus genera associated with lower levels of Atopobium and Prevotella genera as compared to the lipid-improved patients.ConclusionCollectively, these data raise the possibility that the microbial environment surrounding gustatory papillae might play a role in the positive changes of fat taste sensitivity observed in some patients after VSG. |
| first_indexed | 2024-04-10T23:42:09Z |
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| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-10T23:42:09Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-0898e33dc386455f9548684c97ac07792023-01-11T06:25:09ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-01-01910.3389/fnut.2022.10464541046454A specific tongue microbiota signature is found in patients displaying an improvement of orosensory lipid perception after a sleeve gastrectomyArnaud Bernard0Loredana Radoi1Jeffrey Christensen2Florence Servant3Vincent Blasco-Blaque4Séverine Ledoux5Xavier Collet6Philippe Besnard7UMR 1231 INSERM/Univ Bourgogne Franche-Comté/AgroSup Dijon, Dijon, FranceMédecine Bucco-dentaire, Hôpital Louis Mourier (APHP-Nord), Colombes, France & Univ Paris Cité/CESP-UMR 1018 INSERM, Paris, FranceUMR 1297 INSERM/Univ Toulouse III Paul Sabatier, Toulouse, FranceVaiomer, Toulouse, FranceUMR 1297 INSERM/Univ Toulouse III Paul Sabatier, Toulouse, FranceExplorations Fonctionnelles, Hôpital Louis Mourier (APHP-Nord), Colombes, FranceUMR 1297 INSERM/Univ Toulouse III Paul Sabatier, Toulouse, FranceUMR 1231 INSERM/Univ Bourgogne Franche-Comté/AgroSup Dijon, Dijon, FranceIntroductionA preferential consumption of low-fat foods is reported by most of the patients after a vertical sleeve gastrectomy (VSG). The fact that a recent study shed light on a relationship between oral microbiota and fat taste sensitivity in obese patients prompted us to explore whether such a connection also exists in the context of a VSG.MethodsThirty-two adult female patients with a severe obesity (BMI = 43.1 ± 0.7 kg/m2) and candidates for a VSG were selected. Oral microbiota composition surrounding the gustatory circumvallate papillae (CVP) and the lipid perception thresholds were explored before and 6 months after surgery.ResultsVSG was found to be associated both with a qualitative (compositional changes) and quantitative (lower gene richness) remodeling of the peri-CVP microbiota. Analysis of the lipid perception allowed us to distinguish two subgroups: patients with a post-operative improvement of the fat taste sensitivity (i.e., with a lower threshold, n = 14) and unimproved patients (n = 18). Specific peri-CVP microbiota signatures also discriminated these two subgroups, unimproved patient being characterized by higher levels of Porphyromonas, Fusobacterium, and Haemophilus genera associated with lower levels of Atopobium and Prevotella genera as compared to the lipid-improved patients.ConclusionCollectively, these data raise the possibility that the microbial environment surrounding gustatory papillae might play a role in the positive changes of fat taste sensitivity observed in some patients after VSG.https://www.frontiersin.org/articles/10.3389/fnut.2022.1046454/fullfat tastebariatric surgeryoral microbiotacircumvallate papillaeeating behavior |
| spellingShingle | Arnaud Bernard Loredana Radoi Jeffrey Christensen Florence Servant Vincent Blasco-Blaque Séverine Ledoux Xavier Collet Philippe Besnard A specific tongue microbiota signature is found in patients displaying an improvement of orosensory lipid perception after a sleeve gastrectomy Frontiers in Nutrition fat taste bariatric surgery oral microbiota circumvallate papillae eating behavior |
| title | A specific tongue microbiota signature is found in patients displaying an improvement of orosensory lipid perception after a sleeve gastrectomy |
| title_full | A specific tongue microbiota signature is found in patients displaying an improvement of orosensory lipid perception after a sleeve gastrectomy |
| title_fullStr | A specific tongue microbiota signature is found in patients displaying an improvement of orosensory lipid perception after a sleeve gastrectomy |
| title_full_unstemmed | A specific tongue microbiota signature is found in patients displaying an improvement of orosensory lipid perception after a sleeve gastrectomy |
| title_short | A specific tongue microbiota signature is found in patients displaying an improvement of orosensory lipid perception after a sleeve gastrectomy |
| title_sort | specific tongue microbiota signature is found in patients displaying an improvement of orosensory lipid perception after a sleeve gastrectomy |
| topic | fat taste bariatric surgery oral microbiota circumvallate papillae eating behavior |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.1046454/full |
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