Enzymatic synthesis and nanopore sequencing of 12-letter supernumerary DNA

Enzymatic synthesis and nanopore sequencing of 12-letter supernumerary DNA

Abstract The 4-letter DNA alphabet (A, T, G, C) as found in Nature is an elegant, yet non-exhaustive solution to the problem of storage, transfer, and evolution of biological information. Here, we report on strategies for both writing and reading DNA with expanded alphabets composed of up to 12 lett...

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Bibliographic Details
Main Authors: Hinako Kawabe, Christopher A. Thomas, Shuichi Hoshika, Myong-Jung Kim, Myong-Sang Kim, Logan Miessner, Nicholas Kaplan, Jonathan M. Craig, Jens H. Gundlach, Andrew H. Laszlo, Steven A. Benner, Jorge A. Marchand
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42406-z

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https://doi.org/10.1038/s41467-023-42406-z

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