Ig-Like Transcript 2 (ILT2) Blockade and Lenalidomide Restore NK Cell Function in Chronic Lymphocytic Leukemia

Ig-Like Transcript 2 (ILT2) Blockade and Lenalidomide Restore NK Cell Function in Chronic Lymphocytic Leukemia

One of the cardinal features of chronic lymphocytic leukemia (CLL) is its association with a profound immunosuppression. NK cell function is markedly impaired in CLL patients, who show a significant dysregulation of the expression of activating and inhibitory receptors. Here, we analyzed the role of...

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Bibliographic Details
Main Authors: Mónica Villa-Álvarez, Christian Sordo-Bahamonde, Seila Lorenzo-Herrero, Ana P. Gonzalez-Rodriguez, Angel R. Payer, Esther Gonzalez-Garcia, María C. Villa-Álvarez, Alejandro López-Soto, Segundo Gonzalez
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
chronic lymphocytic leukemia
NK cells
ILT2
lenalidomide
IL-2
checkpoint
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02917/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02917/full

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