Detection and Quantification of ctDNA for Longitudinal Monitoring of Treatment in Non-Small Cell Lung Cancer Patients Using a Universal Mutant Detection Assay by Denaturing Capillary Electrophoresis

Detection and Quantification of ctDNA for Longitudinal Monitoring of Treatment in Non-Small Cell Lung Cancer Patients Using a Universal Mutant Detection Assay by Denaturing Capillary Electrophoresis

Background: Observation of anticancer therapy effect by monitoring of minimal residual disease (MRD) is becoming an important tool in management of non-small cell lung cancer (NSCLC). The approach is based on periodic detection and quantification of tumor-specific somatic DNA mutation in circulating...

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Bibliographic Details
Main Authors: Lucie Benesova, Renata Ptackova, Tereza Halkova, Anastasiya Semyakina, Martin Svaton, Ondrej Fiala, Milos Pesek, Marek Minarik
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Pathology and Oncology Research
Subjects:
liquid biopsy
NSCLC
ctDNA
KRAS mutations
minimal residual disease
capillary electrophoresis
Online Access:https://www.por-journal.com/articles/10.3389/pore.2022.1610308/full

Internet

https://www.por-journal.com/articles/10.3389/pore.2022.1610308/full

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