Chemoprevention of skin cancer with 1,1-Bis (3'-indolyl)-1-(aromatic) methane analog through induction of the orphan nuclear receptor, NR4A2 (Nurr1).

Chemoprevention of skin cancer with 1,1-Bis (3'-indolyl)-1-(aromatic) methane analog through induction of the orphan nuclear receptor, NR4A2 (Nurr1).

The objective of this study was to demonstrate the anti-skin cancer and chemopreventive potential of 1,1-bis(3'-indolyl)-1-(p-chlorophenyl methane) (DIM-D) using an in vitro model.In vitro cell cytotoxicity and viability assays were carried out in A431 human epidermoid carcinoma cell line and n...

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Bibliographic Details
Main Authors: Cedar H A Boakye, Ravi Doddapaneni, Punit P Shah, Apurva R Patel, Chandraiah Godugu, Stephen Safe, Santosh K Katiyar, Mandip Singh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3737220?pdf=render

Internet

http://europepmc.org/articles/PMC3737220?pdf=render

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