Mechanism study of Curcumin on inhibiting experimental choroidal neovascularization in vitro by AKT/HIF-1α/VEGF pathway

Mechanism study of Curcumin on inhibiting experimental choroidal neovascularization in vitro by AKT/HIF-1α/VEGF pathway

AIM: To investigate the effect and mechanism of curcumin on inhibiting choroidal neovascularization(CNV)in vitro. METHODS: Human retinal pigment epithelial(ARPE-19)cells chemical hypoxia model was established by cobalt chloride(CoCl2). CCK-8 method was used to detect the effect of curcumin on the ac...

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Bibliographic Details
Main Authors: Shui-Ling Chen, Ze-Feng Kang, Wen-Li Chu, Xue-Lian Hao, Fang-Fang Tao, Ming-Ming Zhang, Shu-Jiao Li
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2022-04-01
Series:Guoji Yanke Zazhi
Subjects:
choroidal neovascularization
curcumin
vascular endothelial growth factor(vegf)
hypoxia-inducible factor-1α(hif-1α)
protein kinase b(akt)
human retinal pigment epithelial cells
human umbilical vein endothelial cells
Online Access:http://ies.ijo.cn/cn_publish/2022/4/202204003.pdf

Internet

http://ies.ijo.cn/cn_publish/2022/4/202204003.pdf

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