Update to the study protocol, including statistical analysis plan, for the multicentre, randomised controlled OuTSMART trial: a combined screening/treatment programme to prevent premature failure of renal transplants due to chronic rejection in patients with HLA antibodies

Update to the study protocol, including statistical analysis plan, for the multicentre, randomised controlled OuTSMART trial: a combined screening/treatment programme to prevent premature failure of renal transplants due to chronic rejection in patients with HLA antibodies

Abstract Background Chronic rejection is the single biggest cause of premature kidney graft failure. HLA antibodies (Ab) are an established prognostic biomarker for premature graft failure so there is a need to test whether treatment decisions based on the presence of the biomarker can alter prognos...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Dominic Stringer, Leanne M. Gardner, Janet L. Peacock, Irene Rebollo-Mesa, Rachel Hilton, Olivia Shaw, Richard Baker, Brendan Clark, Raj C. Thuraisingham, Matthew Buckland, Michael Picton, Judith Worthington, Richard Borrows, David Briggs, Sapna Shah, Kin Yee Shiu, Keith McCullough, Mysore Phanish, Janet Hegarty, John Stoves, Aimun Ahmed, Waqar Ayub, Robert Horne, Paul McCrone, Joanna Kelly, Caroline Murphy, Anthony Dorling
Format: Artykuł
Język:English
Wydane: BMC 2019-08-01
Seria:Trials
Hasła przedmiotowe:
Human leucocyte antigen antibodies
Renal transplantation
Randomised controlled trial
Graft failure
Immunosuppression
Time-to-event
Dostęp online:http://link.springer.com/article/10.1186/s13063-019-3602-2

Internet

http://link.springer.com/article/10.1186/s13063-019-3602-2

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