Bilirubin, a hepatoprotective agent that activates SIRT1, PGC-1α, and PPAR-α, while inhibiting NF-κB in rats with metabolic-associated fatty liver disease

Bilirubin, a hepatoprotective agent that activates SIRT1, PGC-1α, and PPAR-α, while inhibiting NF-κB in rats with metabolic-associated fatty liver disease

Abstract Metabolic-associated fatty liver disease (MAFLD) is a chronic liver disorder characterized by fatty liver disease alongside overweight or obesity and/or type 2 diabetes mellitus (T2DM). Timely intervention is crucial for a potential cure. This study aimed to investigate the effects of bilir...

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Bibliographic Details
Main Authors: Motahareh Taghizadeh, Mohammad Hasan Maleki, Omid Vakili, Ramin Tavakoli, Parvin Zarei, Amirreza Dehghanian, Hossein Bordbar, Sayed Mohammad Shafiee
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Metabolic associated fatty liver disease
Bilirubin
SIRT1
PPAR-α
NF-κB
Inflammation
Online Access:https://doi.org/10.1038/s41598-024-80119-5

Internet

https://doi.org/10.1038/s41598-024-80119-5

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