Selection for CD26− and CD49A+ Cells From Pluripotent Stem Cells-Derived Islet-Like Clusters Improves Therapeutic Activity in Diabetic Mice

Selection for CD26− and CD49A+ Cells From Pluripotent Stem Cells-Derived Islet-Like Clusters Improves Therapeutic Activity in Diabetic Mice

BackgroundCell therapy of diabetes aims at restoring the physiological control of blood glucose by transplantation of functional pancreatic islet cells. A potentially unlimited source of cells for such transplantations would be islet cells derived from an in vitro differentiation of human pluripoten...

Full description

Bibliographic Details
Main Authors: Kfir Molakandov, Denise A. Berti, Avital Beck, Ofer Elhanani, Michael D. Walker, Yoav Soen, Karina Yavriyants, Michal Zimerman, Ella Volman, Itzik Toledo, Anna Erukhimovich, Alon M. Levy, Arik Hasson, Joseph Itskovitz-Eldor, Judith Chebath, Michel Revel
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Endocrinology
Subjects:
human ESC-derived insulin producing cells
islet-like clusters (ILC)
functional cell capture screening
integrin alpha1 (CD49A)
DPP4 (CD26)
alginate encapsulation
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.635405/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2021.635405/full

Similar Items