Tgfβ signaling is critical for maintenance of the tendon cell fate

Tgfβ signaling is critical for maintenance of the tendon cell fate

Studies of cell fate focus on specification, but little is known about maintenance of the differentiated state. In this study, we find that the mouse tendon cell fate requires continuous maintenance in vivo and identify an essential role for TGFβ signaling in maintenance of the tendon cell fate. To...

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Bibliographic Details
Main Authors: Guak-Kim Tan, Brian A Pryce, Anna Stabio, John V Brigande, ChaoJie Wang, Zheng Xia, Sara F Tufa, Douglas R Keene, Ronen Schweitzer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
tendon
TGF-beta signaling
dedifferentiation
Scleraxis
cell fate
tendon degeneration
Online Access:https://elifesciences.org/articles/52695

Internet

https://elifesciences.org/articles/52695

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