IGF-1 Haploinsufficiency Causes Age-Related Chronic Cochlear Inflammation and Increases Noise-Induced Hearing Loss

IGF-1 Haploinsufficiency Causes Age-Related Chronic Cochlear Inflammation and Increases Noise-Induced Hearing Loss

Insulin-like growth factor 1 (IGF-1) deficiency is an ultrarare syndromic human sensorineural deafness. Accordingly, IGF-1 is essential for the postnatal maturation of the cochlea and the correct wiring of hearing in mice. Less severe decreases in human IGF-1 levels have been associated with other h...

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Bibliographic Details
Main Authors: Adelaida M. Celaya, Lourdes Rodríguez-de la Rosa, Jose M. Bermúdez-Muñoz, José M. Zubeldia, Carlos Romá-Mateo, Carlos Avendaño, Federico V. Pallardó, Isabel Varela-Nieto
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cells
Subjects:
AKT
apoptosis
ARHL
IL1β
JNK
NIHL
Online Access:https://www.mdpi.com/2073-4409/10/7/1686

Internet

https://www.mdpi.com/2073-4409/10/7/1686

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