Safety and efficacy of glibenclamide combined with rtPA in acute cerebral ischemia with occlusion/stenosis of anterior circulation (SE-GRACE): a randomized, double-blind, placebo-controlled trialResearch in context

Safety and efficacy of glibenclamide combined with rtPA in acute cerebral ischemia with occlusion/stenosis of anterior circulation (SE-GRACE): a randomized, double-blind, placebo-controlled trialResearch in context

Summary: Background: Glibenclamide alleviates brain edema and improves neurological outcomes in experimental models of stroke. We aimed to assess whether glibenclamide improves functional outcomes in patients with acute ischemic stroke treated with recombinant tissue plasminogen activator (rtPA). M...

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Main Authors: Kaibin Huang, Xiaolin Zhao, Yunxiao Zhao, Guoshuai Yang, Saijun Zhou, Zhi Yang, Wenguo Huang, Guohu Weng, Pingyan Chen, Chongyang Duan, Zhenzhou Lin, Shengnan Wang, Xiangmin Liu, Yunqiang Huang, Jiangshan Zhang, Xu Zhang, Hao Li, Songsheng Ye, Yong Gu, Minzhen Zhu, Weiying Chen, Weiwei Quan, Na Liu, Quanfeng Chen, Yuan Chang, Jinzhao He, Zhong Ji, Yongming Wu, Suyue Pan
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:EClinicalMedicine
Subjects:
Acute ischemic stroke
Recombinant tissue plasminogen activator
Glibenclamide
Brain edema
Neuroinflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537023004820

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http://www.sciencedirect.com/science/article/pii/S2589537023004820

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