Formulation and Evaluation of Hydrophilic Polymer Based Methotrexate Patches: In Vitro and In Vivo Characterization

Formulation and Evaluation of Hydrophilic Polymer Based Methotrexate Patches: In Vitro and In Vivo Characterization

This study attempted to develop and evaluate controlled-release matrix-type transdermal patches with different ratios of hydrophilic polymers (sodium carboxymethylcellulose and hydroxypropyl methylcellulose) for the local delivery of methotrexate. Transdermal patches were formulated by employing a s...

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Bibliographic Details
Main Authors: Muhammad Shahid Latif, Fatemah F. Al-Harbi, Asif Nawaz, Sheikh Abdur Rashid, Arshad Farid, Mohammad Al Mohaini, Abdulkhaliq J. Alsalman, Maitham A. Al Hawaj, Yousef N. Alhashem
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Polymers
Subjects:
sodium carboxymethylcellulose (CMC-Na)
hydroxypropyl methylcellulose (HPMC)
transdermal drug deliveries (TDDs)
methotrexate
transdermal patches
Online Access:https://www.mdpi.com/2073-4360/14/7/1310

Internet

https://www.mdpi.com/2073-4360/14/7/1310

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