Preparation and in vitro evaluation of injectable formulations of levothyroxine sodium using in situ forming hydrogel temperature-responsive systems based on PLA-PEG-PLA and PLGA-PEG-PLGA triblock copolymers

Preparation and in vitro evaluation of injectable formulations of levothyroxine sodium using in situ forming hydrogel temperature-responsive systems based on PLA-PEG-PLA and PLGA-PEG-PLGA triblock copolymers

Objective(s): Recently, great attention has been paid to developing new drug delivery systems to manage the rate, time, and site of drug release. We aimed to design a novel drug delivery system to support targeted and gradual delivery of levothyroxine sodium.Materials and Methods: The triblock copol...

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Bibliographic Details
Main Authors: Jebreel Movafagh, Farzin Hadizadeh, Elham Khodaverdi, Bahnaz Khalili, Seyedeh Nesa Rezaeian Shiadeh, Hossein Kamali, Fatemeh Oroojalian
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2022-03-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
in situ forming hydrogel- gelling
levothyroxine sodium
smart hydrogels
temperature-responsive- systems
triblock copolymer
Online Access:https://ijbms.mums.ac.ir/article_19806_c3295190573f467d756dfb6891a86a19.pdf

Internet

https://ijbms.mums.ac.ir/article_19806_c3295190573f467d756dfb6891a86a19.pdf

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