Preparation, characterization, dissolution, and permeation of flibanserin − 2-HP-β-cyclodextrin inclusion complexes

Preparation, characterization, dissolution, and permeation of flibanserin − 2-HP-β-cyclodextrin inclusion complexes

Flibanserin (FLB), an antiserotonin drug, is used to treat women with hypoactive sexual appetite disorder. FLB shows low bioavailability (~33%) probably due to its low water solubility. The current study investigated the impact of hydroxypropyl-β-cyclodextrin (HP-β-CD) and sodium lauryl sulfate (SLS...

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Bibliographic Details
Main Authors: Adel F. Alghaith, Gamal M. Mahrous, Diaa Eldin Zidan, Nabil A. Alhakamy, Abdulmohsin J. Alamoudi, Awwad A. Radwan
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Saudi Pharmaceutical Journal
Subjects:
Hydroxypropyl-β-cyclodextrin (HP-β-CD)
Sodium lauryl sulfate (SLS)
Flibanserin (FLB)
Solubility
Dissolution
Permeation
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016421001468

Internet

http://www.sciencedirect.com/science/article/pii/S1319016421001468

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