An Overlooked Bone Metabolic Disorder: Cigarette Smoking-Induced Osteoporosis
Cigarette smoking (CS) leads to significant bone loss, which is recognized as an independent risk factor for osteoporosis. The number of smokers is continuously increasing due to the addictive nature of smoking. Therefore it is of great value to effectively prevent CS-induced osteoporosis. However,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/5/806 |
| _version_ | 1797499612388392960 |
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| author | Weidong Weng Hongming Li Sheng Zhu |
| author_facet | Weidong Weng Hongming Li Sheng Zhu |
| author_sort | Weidong Weng |
| collection | DOAJ |
| description | Cigarette smoking (CS) leads to significant bone loss, which is recognized as an independent risk factor for osteoporosis. The number of smokers is continuously increasing due to the addictive nature of smoking. Therefore it is of great value to effectively prevent CS-induced osteoporosis. However, there are currently no effective interventions to specifically counteract CS-induced osteoporosis, owing to the fact that the specific mechanisms by which CS affects bone metabolism are still elusive. This review summarizes the latest research findings of important pathways between CS exposure and bone metabolism, with the aim of providing new targets and ideas for the prevention of CS-induced osteoporosis, as well as providing theoretical directions for further research in the future. |
| first_indexed | 2024-03-10T03:49:54Z |
| format | Article |
| id | doaj.art-08c5872f3af3419e9be9a4c6204bf892 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T03:49:54Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-08c5872f3af3419e9be9a4c6204bf8922023-11-23T11:09:45ZengMDPI AGGenes2073-44252022-04-0113580610.3390/genes13050806An Overlooked Bone Metabolic Disorder: Cigarette Smoking-Induced OsteoporosisWeidong Weng0Hongming Li1Sheng Zhu2Department of Trauma and Reconstructive Surgery, BG Trauma Clinic, Siegfried Weller Institute for Trauma Research, Eberhard Karls University Tuebingen, 72076 Tuebingen, GermanyDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, ChinaCigarette smoking (CS) leads to significant bone loss, which is recognized as an independent risk factor for osteoporosis. The number of smokers is continuously increasing due to the addictive nature of smoking. Therefore it is of great value to effectively prevent CS-induced osteoporosis. However, there are currently no effective interventions to specifically counteract CS-induced osteoporosis, owing to the fact that the specific mechanisms by which CS affects bone metabolism are still elusive. This review summarizes the latest research findings of important pathways between CS exposure and bone metabolism, with the aim of providing new targets and ideas for the prevention of CS-induced osteoporosis, as well as providing theoretical directions for further research in the future.https://www.mdpi.com/2073-4425/13/5/806cigarette smokingosteoporosisRANK-RANKL-OPG pathwayAhR pathway |
| spellingShingle | Weidong Weng Hongming Li Sheng Zhu An Overlooked Bone Metabolic Disorder: Cigarette Smoking-Induced Osteoporosis Genes cigarette smoking osteoporosis RANK-RANKL-OPG pathway AhR pathway |
| title | An Overlooked Bone Metabolic Disorder: Cigarette Smoking-Induced Osteoporosis |
| title_full | An Overlooked Bone Metabolic Disorder: Cigarette Smoking-Induced Osteoporosis |
| title_fullStr | An Overlooked Bone Metabolic Disorder: Cigarette Smoking-Induced Osteoporosis |
| title_full_unstemmed | An Overlooked Bone Metabolic Disorder: Cigarette Smoking-Induced Osteoporosis |
| title_short | An Overlooked Bone Metabolic Disorder: Cigarette Smoking-Induced Osteoporosis |
| title_sort | overlooked bone metabolic disorder cigarette smoking induced osteoporosis |
| topic | cigarette smoking osteoporosis RANK-RANKL-OPG pathway AhR pathway |
| url | https://www.mdpi.com/2073-4425/13/5/806 |
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