Dihydromyricetin alleviates methotrexate-induced hepatotoxicity via suppressing the ‎TLR4/NF-κB pathway and NLRP3 inflammasome/caspase 1 axis

Dihydromyricetin alleviates methotrexate-induced hepatotoxicity via suppressing the ‎TLR4/NF-κB pathway and NLRP3 inflammasome/caspase 1 axis

The anticancer drug methotrexate (MTX) is known to cause hepatotoxicity as a possibly fatal adverse effect that hinders its clinical application. Although the natural flavonoid, dihydromyricetin (DHM), has antioxidant and anti-inflammatory effects; its role against MTX-induced hepatotoxicity has not...

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Bibliographic Details
Main Authors: Asmaa I. Matouk, Eman M. Awad, Nashwa F.G. El-Tahawy, Azza A.K. El-Sheikh, Shaimaa Waz
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Methotrexate
Dihydromyricetin
TLR4
NF-κB
NLRP3
Caspase 1
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222011416

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http://www.sciencedirect.com/science/article/pii/S0753332222011416

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