Mechanisms of glabridin inhibition of integrin αIIbβ3 inside-out signals and NF-κB activation in human platelets

Mechanisms of glabridin inhibition of integrin αIIbβ3 inside-out signals and NF-κB activation in human platelets

Abstract Background Platelets play a crucial role in cardiovascular diseases (CVDs) and are activated by endogenous agonists like collagen. These agonists initiate signal transduction through specific platelet receptors, resulting in platelet aggregation. Glabridin, a prenylated isoflavonoid found i...

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Bibliographic Details
Main Authors: Wei-Chieh Huang, Thanasekaran Jayakumar, Joen-Rong Sheu, Chih-Wei Hsia, Chih-Hsuan Hsia, Ting-Lin Yen, Chao-Chien Chang
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Chinese Medicine
Subjects:
Glabridin
Human platelets
αIIbβ3 inside-out
NF-κB
Thromboembolic lungs
Platelet plug formation
Online Access:https://doi.org/10.1186/s13020-023-00779-9

Internet

https://doi.org/10.1186/s13020-023-00779-9

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