IRAG1 Deficient Mice Develop PKG1β Dependent Pulmonary Hypertension

IRAG1 Deficient Mice Develop PKG1β Dependent Pulmonary Hypertension

PKGs are serine/threonine kinases. PKG1 has two isoforms—PKG1α and β. Inositol trisphosphate receptor (IP<sub>3</sub>R)-associated cGMP-kinase substrate 1 (IRAG1) is a substrate for PKG1β. IRAG1 is also known to further interact with IP<sub>3</sub>RI, which mediates intracell...

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Bibliographic Details
Main Authors: Siladitta Biswas, Baktybek Kojonazarov, Stefan Hadzic, Michael Majer, Ganimete Bajraktari, Tatyana Novoyatleva, Hossein Ardeschir Ghofrani, Friedrich Grimminger, Werner Seeger, Norbert Weissmann, Jens Schlossmann, Ralph Theo Schermuly
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cells
Subjects:
IRAG1
PKG1β
Pulmonary Hypertension
PASMC
RV dysfunction
Online Access:https://www.mdpi.com/2073-4409/9/10/2280

Internet

https://www.mdpi.com/2073-4409/9/10/2280

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