Dereplication of Natural Product Antifungals via Liquid Chromatography–Tandem Mass Spectrometry and Chemical Genomics

Dereplication of Natural Product Antifungals via Liquid Chromatography–Tandem Mass Spectrometry and Chemical Genomics

Recently expanded reports of multidrug-resistant fungal infections underscore the need to develop new and more efficient methods for antifungal drug discovery. A ubiquitous problem in natural product drug discovery campaigns is the rediscovery of known compounds or their relatives; accordingly, we h...

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Bibliographic Details
Main Authors: Nathaniel J. Brittin, David J. Aceti, Doug R. Braun, Josephine M. Anderson, Spencer S. Ericksen, Scott R. Rajski, Cameron R. Currie, David R. Andes, Tim S. Bugni
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Molecules
Subjects:
antifungal
natural products
mechanism of action
dereplication
chemical genomics
metabolomics
Online Access:https://www.mdpi.com/1420-3049/30/1/77

Internet

https://www.mdpi.com/1420-3049/30/1/77

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