Dual Nucleosomal Double-Strand Breaks Are the Key Effectors of Curative Radiation Therapy

Dual Nucleosomal Double-Strand Breaks Are the Key Effectors of Curative Radiation Therapy

Most ionizing radiation produces <i>δ</i>-rays of ≈1 keV that can impart MGy doses to 100 nm<sup>3</sup> volumes of DNA. These events can produce severe dual double-strand breaks (DDSBs) on nucleosomes, particularly in dense heterochromatic DNA. This is the most common multip...

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Bibliographic Details
Main Authors: Anders Brahme, Yvonne Lorat
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Biophysica
Subjects:
dual double-strand breaks
dual nucleosomal DSB repair
DSB imaging
TP53 damage sensors and modification sites
light ion radiation therapy
therapy optimization
Online Access:https://www.mdpi.com/2673-4125/3/4/45

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https://www.mdpi.com/2673-4125/3/4/45

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