Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP

Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP

Cholesterol homeostasis is maintained through concerted action of the SREBPs and LXRs. Here, we report that RNF145, a previously uncharacterized ER membrane ubiquitin ligase, participates in crosstalk between these critical signaling pathways. RNF145 expression is induced in response to LXR activati...

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Bibliographic Details
Main Authors: Li Zhang, Prashant Rajbhandari, Christina Priest, Jaspreet Sandhu, Xiaohui Wu, Ryan Temel, Antonio Castrillo, Thomas Q de Aguiar Vallim, Tamer Sallam, Peter Tontonoz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-10-01
Series:eLife
Subjects:
cholesterol
LXR
nuclear receptor
lipid metabolism
Online Access:https://elifesciences.org/articles/28766

Internet

https://elifesciences.org/articles/28766

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