Molecular Determinants of Mechanical Itch Sensitization in Chronic Itch

Chronic itch is associated with sensitization of the somatosensory nervous system. Recent studies have identified the neural circuits transmitting acute itch; however, the mechanisms by which itch transforms into a pathological state remain largely unknown. We have previously shown that Aβ low-thres...

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Bibliographic Details
Main Authors: Hankyu Lee, Robert D. Graham, Diana Melikyan, Brennan Smith, Ehsan Mirzakhalili, Scott F. Lempka, Bo Duan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.937890/full