Natural statin derivatives as potential therapy to reduce intestinal fluid loss in cholera.

As a leading cause of death in children under 5 years old, secretory diarrheas including cholera are characterized by excessive intestinal fluid secretion driven by enterotoxin-induced cAMP-dependent intestinal chloride transport. This study aimed to identify fungal bioactive metabolites possessing...

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Bibliographic Details
Main Authors: Rattikarn Noitem, Pawin Pongkorpsakol, Chartchai Changsen, Yaowapa Sukpondma, Chittreeya Tansakul, Vatcharin Rukachaisirikul, Chatchai Muanprasat
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-12-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0010989