SARS-CoV-2 SUD2 and Nsp5 Conspire to Boost Apoptosis of Respiratory Epithelial Cells via an Augmented Interaction with the G-Quadruplex of BclII

SARS-CoV-2 SUD2 and Nsp5 Conspire to Boost Apoptosis of Respiratory Epithelial Cells via an Augmented Interaction with the G-Quadruplex of BclII

ABSTRACT The molecular mechanisms underlying how SUD2 recruits other proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to exert its G-quadruplex (G4)-dependent pathogenic function is unknown. Herein, Nsp5 was singled out as a binding partner of the SUD2-N+M domains (SUD2core)...

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Bibliographic Details
Main Authors: Ying Li, Quanwei Yu, Ridong Huang, Hai Chen, Hequan Ren, Lingling Ma, Yang He, Weimin Li
Format: Article
Language:English
Published: American Society for Microbiology 2023-04-01
Series:mBio
Subjects:
DNA topology
epithelial cells
gene expression
protein-DNA interactions
protein-protein interactions
Online Access:https://journals.asm.org/doi/10.1128/mbio.03359-22

Internet

https://journals.asm.org/doi/10.1128/mbio.03359-22

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