Optimization of an Efficient Cell Culture Hepatitis B Infection System for Assessment of Hepatitis B Virus Neutralizing Monoclonal Antibodies

Optimization of an Efficient Cell Culture Hepatitis B Infection System for Assessment of Hepatitis B Virus Neutralizing Monoclonal Antibodies

Background: Human polyclonal plasma-derived hepatitis B immunoglobulin (HBIG) is currently used for immunoprophylaxis of HBV infection. The development of virus-neutralizing monoclonal antibodies (MAbs) requires the use of optimized cell culture systems supporting HBV infection.Objective: This study...

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Bibliographic Details
Main Authors: Hamzeh Sarvnaz, Sahar Asadi-Asadabad, Mohammad Mehdi Amiri, Mojgan Ghaedi, Ulrike Protzer, Mahmood Jeddi-Tehrani, Forough Golsaz-Shirazi, Fazel Shokri
Format: Article
Language:English
Published: Shiraz University of Medical Sciences 2022-09-01
Series:Iranian Journal of Immunology
Subjects:
hbe antigen
hbs antigen
hepatitis b virus
hepg2-ntcp cells
Online Access:https://iji.sums.ac.ir/article_48688_dfc44f9e88149c1464b4e0193c1a9140.pdf

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https://iji.sums.ac.ir/article_48688_dfc44f9e88149c1464b4e0193c1a9140.pdf

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