Targeting of G-protein coupled receptor 40 alleviates airway hyperresponsiveness through RhoA/ROCK1 signaling pathway in obese asthmatic mice

Targeting of G-protein coupled receptor 40 alleviates airway hyperresponsiveness through RhoA/ROCK1 signaling pathway in obese asthmatic mice

Abstract Obesity increases the severity of airway hyperresponsiveness (AHR) in individuals with asthma, but the mechanism is not well elucidated. G-protein coupled receptor 40 (GPR40) has been found to induce airway smooth muscle contraction after activated by long-chain fatty acids (LC-FFAs), sugge...

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Bibliographic Details
Main Authors: Xixi Lin, Like Wang, Xiaojie Lu, Yuanyuan Zhang, Rongying Zheng, Ruijie Chen, Weixi Zhang
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Respiratory Research
Subjects:
GPR40
Asthma
Obesity
RhoA/ROCK1
Airway hyperresponsiveness
Online Access:https://doi.org/10.1186/s12931-023-02361-1

Internet

https://doi.org/10.1186/s12931-023-02361-1

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