Tumor-Derived Extracellular Vesicles Impair CD171-Specific CD4+ CAR T Cell Efficacy

Tumor-Derived Extracellular Vesicles Impair CD171-Specific CD4+ CAR T Cell Efficacy

Chimeric antigen receptor (CAR) T cell efficacy against solid tumors is currently limited by several immune escape mechanisms, which may include tumor-derived extracellular vesicles. Advanced neuroblastoma is an aggressive childhood tumor without curative treatment options for most relapsed patients...

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Bibliographic Details
Main Authors: Solin Ali, Karin Toews, Silke Schwiebert, Anika Klaus, Annika Winkler, Laura Grunewald, Lena Oevermann, Hedwig E. Deubzer, Alicia Tüns, Michael C. Jensen, Anton G. Henssen, Angelika Eggert, Johannes H. Schulte, Esther Schwich, Vera Rebmann, Alexander Schramm, Annette Künkele
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
immunotherapy
pediatric oncology
neuroblastoma
solid tumors
neurotrophic receptor tyrosine kinase
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00531/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00531/full

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