A stable, engineered TL1A ligand co-stimulates T cells via specific binding to DR3

A stable, engineered TL1A ligand co-stimulates T cells via specific binding to DR3

Abstract TL1A (TNFSF15) is a TNF superfamily ligand which can bind the TNFRSF member death receptor 3 (DR3) on T cells and the soluble decoy receptor DcR3. Engagement of DR3 on CD4+ or CD8+ effector T cells by TL1A induces downstream signaling, leading to proliferation and an increase in secretion o...

Full description

Bibliographic Details
Main Authors: Adam Zwolak, Szeman Ruby Chan, Paul Harvilla, Sally Mahady, Anthony A. Armstrong, Leopoldo Luistro, Ninkka Tamot, Douglas Yamada, Mehabaw Derebe, Steven Pomerantz, Mark Chiu, Rajkumar Ganesan, Partha Chowdhury
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-24984-y

Internet

https://doi.org/10.1038/s41598-022-24984-y

Similar Items