Libertellenone T, a Novel Compound Isolated from Endolichenic Fungus, Induces G2/M Phase Arrest, Apoptosis, and Autophagy by Activating the ROS/JNK Pathway in Colorectal Cancer Cells

Libertellenone T, a Novel Compound Isolated from Endolichenic Fungus, Induces G2/M Phase Arrest, Apoptosis, and Autophagy by Activating the ROS/JNK Pathway in Colorectal Cancer Cells

Colorectal cancer (CRC) is the third most deadly type of cancer in the world and continuous investigations are required to discover novel therapeutics for CRC. Induction of apoptosis is one of the promising strategies to inhibit cancers. Here, we have identified a novel compound, Libertellenone T (&...

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Bibliographic Details
Main Authors: Chathurika D. B. Gamage, Jeong-Hyeon Kim, Yi Yang, İsa Taş, So-Yeon Park, Rui Zhou, Sultan Pulat, Mücahit Varlı, Jae-Seoun Hur, Sang-Jip Nam, Hangun Kim
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cancers
Subjects:
CRC
Libertellenone T
G2/M phase arrest
apoptosis
autophagy
ROS/JNK signaling
Online Access:https://www.mdpi.com/2072-6694/15/2/489

Internet

https://www.mdpi.com/2072-6694/15/2/489

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