Effect of the 5-HT4 receptor agonist tegaserod on the expression of GRK2 and GRK6 in the rat gastrointestinal tract

Effect of the 5-HT4 receptor agonist tegaserod on the expression of GRK2 and GRK6 in the rat gastrointestinal tract

Abstract Objective Tegaserod is a 5-hydroxytryptamine type 4 (5-HT4) receptor agonist, formerly used in treating constipation predominant irritable bowel syndrome, which desensitizes 5-HT4 receptors in rat oesophagus and colon in vitro. Desensitization of 5-HT4 receptors is regulated by G-protein co...

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Bibliographic Details
Main Authors: Teshome Nedi, Paul J. White, Ian M. Coupar, Helen R. Irving
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Research Notes
Subjects:
Colon
Oesophagus
5-HT4 receptors
G protein coupled receptor kinases
Receptor desensitization
Online Access:http://link.springer.com/article/10.1186/s13104-018-3495-2

Internet

http://link.springer.com/article/10.1186/s13104-018-3495-2

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