Metformin and adipose-derived stem cell combination therapy alleviates radiation-induced skin fibrosis in mice

Metformin and adipose-derived stem cell combination therapy alleviates radiation-induced skin fibrosis in mice

Abstract Background Radiation therapy often leads to late radiation-induced skin fibrosis (RISF), causing movement impairment and discomfort. We conducted a comprehensive study to assess the effectiveness of metformin and adipose-derived stem cells (ASCs), whether autologous or allogeneic, individua...

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Bibliographic Details
Main Authors: Hamid Malekzadeh, Yusuf Surucu, Somaiah Chinnapaka, Katherine S. Yang, José A. Arellano, Yasamin Samadi, Michael W. Epperly, Joel S. Greenberger, J. Peter Rubin, Asim Ejaz
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Stem Cell Research & Therapy
Subjects:
Radiation
Fibrosis
Metformin
Prophylactic therapy
Adipose stem cells
Online Access:https://doi.org/10.1186/s13287-023-03627-7

Internet

https://doi.org/10.1186/s13287-023-03627-7

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