Identification of Autophagy as a Functional Target Suitable for the Pharmacological Treatment of Mitochondrial Membrane Protein-Associated Neurodegeneration (MPAN) In Vitro

Identification of Autophagy as a Functional Target Suitable for the Pharmacological Treatment of Mitochondrial Membrane Protein-Associated Neurodegeneration (MPAN) In Vitro

Mitochondrial membrane protein-associated neurodegeneration (MPAN) is a relentlessly progressive neurodegenerative disorder caused by mutations in the <i>C19orf12</i> gene. C19orf12 has been implicated in playing a role in lipid metabolism, mitochondrial function, and autophagy, however,...

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Bibliographic Details
Main Authors: Enrica Zanuttigh, Kevork Derderian, Miriam A. Güra, Arie Geerlof, Ivano Di Meo, Chiara Cavestro, Stefan Hempfling, Stephanie Ortiz-Collazos, Mario Mauthe, Tomasz Kmieć, Eugenia Cammarota, Maria Carla Panzeri, Thomas Klopstock, Michael Sattler, Juliane Winkelmann, Ana C. Messias, Arcangela Iuso
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceutics
Subjects:
C19orf12
mitochondria membrane protein-associated neurodegeneration (MPAN)
neurodegeneration with brain iron accumulation (NBIA)
autophagy
LC3
carbamazepine
Online Access:https://www.mdpi.com/1999-4923/15/1/267

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https://www.mdpi.com/1999-4923/15/1/267

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