Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variant

Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variant

Objective: Glucose-dependent insulinotropic polypeptide (GIP) has a role in controlling postprandial metabolic tone. In humans, a GIP receptor (GIPR) variant (Q354, rs1800437) is associated with a lower body mass index (BMI) and increased risk for Type 2 Diabetes. To better understand the impacts of...

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Bibliographic Details
Main Authors: Lucie Yammine, Belén Picatoste, Nazish Abdullah, Rosemary A. Leahey, Emma F. Johnson, Nicolás Gómez-Banoy, Carolina Rosselot, Jennifer Wen, Tahmina Hossain, Marcus D. Goncalves, James C. Lo, Adolfo Garcia-Ocaña, Timothy E. McGraw
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Metabolism
Subjects:
GIPR
Incretin
Glucose metabolism
Diabetes
Receptor trafficking
Pancreatic islets
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877823001655

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http://www.sciencedirect.com/science/article/pii/S2212877823001655

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