Enhanced hippocampal neurogenesis mediated by PGC-1α-activated OXPHOS after neonatal low-dose Propofol exposure

Enhanced hippocampal neurogenesis mediated by PGC-1α-activated OXPHOS after neonatal low-dose Propofol exposure

BackgroundDeveloping brain is highly plastic and can be easily affected. Growing pediatric usage of anesthetics during painless procedures has raised concerns about the effect of low-dose anesthetics on neurodevelopment. It is urgent to ascertain the neuronal effect of low-dose Propofol, a widely us...

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Bibliographic Details
Main Authors: Keyu Chen, Dihan Lu, Xiaoyu Yang, Rui Zhou, Liangtian Lan, Yan Wu, Chen Wang, Xuanxian Xu, Mei Hua Jiang, Ming Wei, Xia Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
Propofol
hippocampal neurogenesis
neural stem cell
OXPHOS
PGC-1α
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.925728/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2022.925728/full

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