Why Does the Type of Halogen Atom Matter for the Radiosensitizing Properties of 5-Halogen Substituted 4-Thio-2′-Deoxyuridines?

Why Does the Type of Halogen Atom Matter for the Radiosensitizing Properties of 5-Halogen Substituted 4-Thio-2′-Deoxyuridines?

Radiosensitizing properties of substituted uridines are of great importance for radiotherapy. Very recently, we confirmed 5-iodo-4-thio-2′-deoxyuridine (ISdU) as an efficient agent, increasing the extent of tumor cell killing with ionizing radiation. To our surprise, a similar derivative o...

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Bibliographic Details
Main Authors: Paulina Spisz, Magdalena Zdrowowicz, Samanta Makurat, Witold Kozak, Konrad Skotnicki, Krzysztof Bobrowski, Janusz Rak
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Molecules
Subjects:
radiosensitizers
stationary radiolysis
pulse radiolysis
modified nucleosides
cellular response
Online Access:https://www.mdpi.com/1420-3049/24/15/2819

Internet

https://www.mdpi.com/1420-3049/24/15/2819

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