Liraglutide Increases VEGF Expression via CNPY2-PERK Pathway Induced by Hypoxia/Reoxygenation Injury

Liraglutide Increases VEGF Expression via CNPY2-PERK Pathway Induced by Hypoxia/Reoxygenation Injury

Liraglutide (Lir) is a glucagon-like peptide-1 receptor agonist that lowers blood sugar and reduces myocardial infarct size by improving endothelial cell function. However, its mechanism has not yet been clarified. Unfolded protein response (UPR) plays an important role in the pathogenesis of myocar...

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Bibliographic Details
Main Authors: Chong Liu, Yong Liu, Jing He, Rong Mu, Yanbo Di, Na Shen, Xuan Liu, Xiao Gao, Jinhui Wang, Tie Chen, Tao Fang, Huanming Li, Fengshi Tian
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Pharmacology
Subjects:
liraglutide
angiogenesis
CNPY2
unfolded protein response
hypoxia/reoxygenation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00789/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00789/full

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