Cellular metabolism constrains innate immune responses in early human ontogeny

Cellular metabolism constrains innate immune responses in early human ontogeny

Little is known about developmental set points of immune responses, especially in humans. Here the authors show that the metabolic state of monocytes isolated from prematurely born infants underlies attenuated responsiveness to fungal infection via selective control of protein translation.

Bibliographic Details
Main Authors: Bernard Kan, Christina Michalski, Helen Fu, Hilda H. T. Au, Kelsey Lee, Elizabeth A. Marchant, Maye F. Cheng, Emily Anderson-Baucum, Michal Aharoni-Simon, Peter Tilley, Raghavendra G. Mirmira, Colin J. Ross, Dan S. Luciani, Eric Jan, Pascal M. Lavoie
Format: Article
Language:English
Published: Nature Portfolio 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07215-9

Internet

https://doi.org/10.1038/s41467-018-07215-9

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