Cellular metabolism constrains innate immune responses in early human ontogeny
Little is known about developmental set points of immune responses, especially in humans. Here the authors show that the metabolic state of monocytes isolated from prematurely born infants underlies attenuated responsiveness to fungal infection via selective control of protein translation.
Bibliographic Details
| Main Authors: |
Bernard Kan,
Christina Michalski,
Helen Fu,
Hilda H. T. Au,
Kelsey Lee,
Elizabeth A. Marchant,
Maye F. Cheng,
Emily Anderson-Baucum,
Michal Aharoni-Simon,
Peter Tilley,
Raghavendra G. Mirmira,
Colin J. Ross,
Dan S. Luciani,
Eric Jan,
Pascal M. Lavoie |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2018-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-07215-9
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