m6A eraser FTO modulates autophagy by targeting SQSTM1/P62 in the prevention of canagliflozin against renal fibrosis

m6A eraser FTO modulates autophagy by targeting SQSTM1/P62 in the prevention of canagliflozin against renal fibrosis

The dysregulation of autophagy contributes to renal fibrosis. N6-Methyladenosine (m6A) RNA modification is a critical mediator of autophagy. Our previous studies have reported that the disorder of the PPARα/fatty acid oxidation (FAO) axis in renal tubular cells is suppressed by STAT6, which is invol...

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Bibliographic Details
Main Authors: Youjing Yang, Qianmin Li, Yi Ling, Linxin Leng, Yu Ma, Lian Xue, Guoyuan Lu, Yue Ding, Jianzhong Li, Shasha Tao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
autophagy
canagliflozin
N6-methyladenosine
renal fibrosis
SQSTM1
STAT6
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1094556/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1094556/full

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