BACE1 and SCD1 are associated with neurodegeneration

BACE1 and SCD1 are associated with neurodegeneration

IntroductionProteolytic processing of amyloid protein precursor by β-site secretase enzyme (BACE1) is dependent on the cellular lipid composition and is affected by endomembrane trafficking in dementia and Alzheimer's disease (AD). Stearoyl-CoA desaturase 1 (SCD1) is responsible for the synthes...

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Main Authors: Ferley A. Bedoya-Guzmán, Mar Pacheco-Herrero, Ivan Daniel Salomon-Cruz, Angela Maria Barrera-Sandoval, Johanna Andrea Gutierrez Vargas, Javier Gustavo Villamil-Ortiz, Carlos Andres Villegas Lanau, Julián David Arias-Londoño, Estela Area-Gomez, Gloria Patricia Cardona Gomez
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
BACE1
SCD1
neurodegeneration
phospholipids
PUFAs
pro-inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1194203/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2023.1194203/full

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