4-Hydroxynonenal Modulates Blood–Brain Barrier Permeability In Vitro through Changes in Lipid Composition and Oxidative Status of Endothelial Cells and Astrocytes

4-Hydroxynonenal Modulates Blood–Brain Barrier Permeability In Vitro through Changes in Lipid Composition and Oxidative Status of Endothelial Cells and Astrocytes

Blood brain barrier (BBB) is a dynamic interface responsible for proper functioning of brain, but also a major obstacle for effective treatment of neurological diseases. Increased levels of free radicals, in high ferrous and high lipid content surrounding, induce lipid peroxidation, leading to produ...

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Bibliographic Details
Main Authors: Marina Cindrić, Ana Čipak Gašparović, Lidija Milković, Ivana Tartaro Bujak, Branka Mihaljević, Neven Žarković, Kamelija Žarković
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
blood–brain barrier
astrocytes
4-hydroxynonenal
lipid composition
Online Access:https://www.mdpi.com/1422-0067/23/22/14373

Internet

https://www.mdpi.com/1422-0067/23/22/14373

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