Analysis of aberrant methylation on promoter sequences of tumor suppressor genes and total DNA in sputum samples: a promising tool for early detection of COPD and lung cancer in smokers

Analysis of aberrant methylation on promoter sequences of tumor suppressor genes and total DNA in sputum samples: a promising tool for early detection of COPD and lung cancer in smokers

<p>Abstract</p> <p>Background</p> <p>Chronic obstructive pulmonary disease (COPD) is a disorder associated to cigarette smoke and lung cancer (LC). Since epigenetic changes in oncogenes and tumor suppressor genes (TSGs) are clearly important in the development of LC. In...

Full description

Bibliographic Details
Main Authors: Guzmán Leda, Depix María, Salinas Ana, Roldán Rosa, Aguayo Francisco, Silva Alejandra, Vinet Raul
Format: Article
Language:English
Published: BMC 2012-07-01
Series:Diagnostic Pathology
Subjects:
DNA methylation
Sputum
Lung cancer
COPD
Online Access:http://www.diagnosticpathology.org/content/7/1/87

Internet

http://www.diagnosticpathology.org/content/7/1/87

Similar Items