Analysis of aberrant methylation on promoter sequences of tumor suppressor genes and total DNA in sputum samples: a promising tool for early detection of COPD and lung cancer in smokers

Analysis of aberrant methylation on promoter sequences of tumor suppressor genes and total DNA in sputum samples: a promising tool for early detection of COPD and lung cancer in smokers

<p>Abstract</p> <p>Background</p> <p>Chronic obstructive pulmonary disease (COPD) is a disorder associated to cigarette smoke and lung cancer (LC). Since epigenetic changes in oncogenes and tumor suppressor genes (TSGs) are clearly important in the development of LC. In...

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Bibliographic Details
Main Authors: Guzmán Leda, Depix María, Salinas Ana, Roldán Rosa, Aguayo Francisco, Silva Alejandra, Vinet Raul
Format: Article
Language:English
Published: BMC 2012-07-01
Series:Diagnostic Pathology
Subjects:
DNA methylation
Sputum
Lung cancer
COPD
Online Access:http://www.diagnosticpathology.org/content/7/1/87

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