Correlation of plasma cell assessment by phenotypic methods and molecular profiles by NGS in patients with plasma cell dyscrasias

Correlation of plasma cell assessment by phenotypic methods and molecular profiles by NGS in patients with plasma cell dyscrasias

Abstract Background Next-generation sequencing (NGS) detects somatic mutations in a high proportion of plasma cell dyscrasias (PCD), but is currently not integrated into diagnostic routine. We correlated NGS data with degree of bone marrow (BM) involvement by cytomorphology (BMC), histopathology (BM...

Full description

Bibliographic Details
Main Authors: Ekaterina Rebmann Chigrinova, Naomi A. Porret, Martin Andres, Gertrud Wiedemann, Yara Banz, Myriam Legros, Matthias Pollak, Elisabeth Oppliger Leibundgut, Thomas Pabst, Ulrike Bacher
Format: Article
Language:English
Published: BMC 2022-09-01
Series:BMC Medical Genomics
Subjects:
Multiple myeloma
NGS
Bone marrow aspirate
Flow cytometry
Trephine biopsy
Histopathology
Online Access:https://doi.org/10.1186/s12920-022-01346-1

Internet

https://doi.org/10.1186/s12920-022-01346-1

Similar Items