Pirfenidone Inhibits Alveolar Bone Loss in Ligature-Induced Periodontitis by Suppressing the NF-κB Signaling Pathway in Mice

Pirfenidone Inhibits Alveolar Bone Loss in Ligature-Induced Periodontitis by Suppressing the NF-κB Signaling Pathway in Mice

There has been increasing interest in adjunctive use of anti-inflammatory drugs to control periodontitis. This study was performed to examine the effects of pirfenidone (PFD) on alveolar bone loss in ligature-induced periodontitis in mice and identify the relevant mechanisms. Experimental periodonti...

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Bibliographic Details
Main Authors: Zijiao Zhang, Juhan Song, Seung-Hee Kwon, Zhao Wang, Suk-Gyun Park, Xianyu Piao, Je-Hwang Ryu, Nacksung Kim, Ok-Su Kim, Sun-Hun Kim, Jeong-Tae Koh
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
pirfenidone
periodontitis
osteoclast differentiation
alveolar bone loss
inflammation
NF-κB pathway
Online Access:https://www.mdpi.com/1422-0067/24/10/8682

Internet

https://www.mdpi.com/1422-0067/24/10/8682

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