Synthesis, molecular docking and biological potentials of new 2-(4-(2-chloroacetyl) piperazin-1-yl)-N-(2-(4-chlorophenyl)-4-oxoquinazolin-3(4H)-yl)acetamide derivatives

Synthesis, molecular docking and biological potentials of new 2-(4-(2-chloroacetyl) piperazin-1-yl)-N-(2-(4-chlorophenyl)-4-oxoquinazolin-3(4H)-yl)acetamide derivatives

Abstract In the present study, a series of 2-(4-(2-chloroacetyl)piperazin-1-yl)-N-(2-(4-chlorophenyl)-4-oxoquinazolin-3(4H)-yl)acetamide derivatives was synthesized and its chemical structures were confirmed by physicochemical and spectral characteristics. The synthesized compounds were evaluated fo...

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Bibliographic Details
Main Authors: Shinky Mehta, Sanjiv Kumar, Rakesh Kumar Marwaha, Balasubramanian Narasimhan, Kalavathy Ramasamy, Siong Meng Lim, Syed Adnan Ali Shah, Vasudevan Mani
Format: Article
Language:English
Published: BMC 2019-09-01
Series:BMC Chemistry
Subjects:
Quinazolinones
Antimicrobial
Anticancer potential
HCT116
RAW264.7
Molecular docking
Online Access:http://link.springer.com/article/10.1186/s13065-019-0629-0

Internet

http://link.springer.com/article/10.1186/s13065-019-0629-0

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