Impact of HepG2 Cells Glutathione Depletion on Neutral Sphingomyelinases mRNA Levels and Activity

Impact of HepG2 Cells Glutathione Depletion on Neutral Sphingomyelinases mRNA Levels and Activity

Liver cancer is a prevalent form of cancer worldwide. While research has shown that increasing sphingomyelin (SM) hydrolysis by activating the cell surface membrane-associated neutral sphingomyelinase 2 (nSMase2) can control cell proliferation and apoptosis, the role of total glutathione depletion i...

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Bibliographic Details
Main Authors: Marie Gamal, Hatem Tallima, Hassan M. E. Azzazy, Anwar Abdelnaser
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Current Issues in Molecular Biology
Subjects:
HCC
HepG2 cells
sphingomyelin
sphingomyelinase
glutathione
ROS
Online Access:https://www.mdpi.com/1467-3045/45/6/318

Internet

https://www.mdpi.com/1467-3045/45/6/318

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