Dynamical model of the CLC-2 ion channel reveals conformational changes associated with selectivity-filter gating.
This work reports a dynamical Markov state model of CLC-2 "fast" (pore) gating, based on 600 microseconds of molecular dynamics (MD) simulation. In the starting conformation of our CLC-2 model, both outer and inner channel gates are closed. The first conformational change in our dataset in...
| প্রধান লেখক: | , , , |
|---|---|
| বিন্যাস: | প্রবন্ধ |
| ভাষা: | English |
| প্রকাশিত: |
Public Library of Science (PLoS)
2020-03-01
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| মালা: | PLoS Computational Biology |
| অনলাইন ব্যবহার করুন: | https://doi.org/10.1371/journal.pcbi.1007530 |